Look closely at the evidence for and against each hypothesis, and then write a 3-4 paragraph essay describing which hypothesis you think is most likely to be true based on the evidence. Consider whether the selective force (the disease) was strong enough in Europe to give heterozygotes an advantage over other genotypes. In your essay, you must discuss the evidence for and against each of the three hypotheses, and then detail why you think one hypothesis is more supported than the others.