“What is this so-called ‘problem of personal identity?'” Your response must include: What are the problems? What are some solutions that have been offered? What is at stake in this discussion (why does it matter)?
Describe Ban on caricatures of the prophet Muhammad.
Explain your purpose for graduate study, including your current degree goals and reasons for selecting a particular field of study.
Describe Hudson River School art movement.
Write a paper discussing the Israeli Art on the Holocaust.
a.What actual amino acids are different in this mutant compared to wild-type P450BM-3? What are some of the known roles (in wild-type P450BM-3) of the changed amino acids?b.What are the major products produced by the mutant when it is given noscapine as a substrate? (Hint: Find the ‘supplementary material’ for the article for the best data.)c.What is its ‘coupling efficiency’. What does this mean? How did the authors measure it?d.What is the paper’s overall goal for the study, and does this mutant achieve their goal? Is it the best mutant at achieving their goal?e.Which of the human P450s tested in the Fang et al. paper is the VA mutant most like in terms of products that it forms?2.In the Fang et al. article, they use a ‘dual-activity’ incubation system. a.What are the two activities, and why are both parts required to get the desired products? b.For UGT1A1, which glucuronide metabolites (C1, C3, or C4) was it capable of producing?c.In figure 6 panel A, it is shown that the products formed in the presence of NADPH but not GSH are different than those formed from the presence of both, and that the products formed in the presence of GSH but not NADPH are different that either of the other two sets of products. What does all of this tell us about the pathway generating the metabolites?d.Stare in awe at Figure 8 in all its glory. What is the difference between structure I and structure X? How do compounds VIII and IX relate to each other?For question 3, read this article:Zhang RK, Chen K, Huang X, Wohlschlager L, Renata H, Arnold FH. Enzymatic assembly of carbon-carbon bonds via iron-catalysed sp(3) C-H functionalization. Nature. 2019 Jan;565(7737):67-72. doi: 10.1038/s41586-018-0808-5. Epub 2018 Dec 19. PubMed PMID: 30568304; PubMed Central PMCID: PMC6440214. Read free at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440214/3.This paper (which has 160 pages of supplementary material) was submitted in July 2018, accepted in November 2018, and published in December 2018. The corresponding author, Francis Arnold, won the Nobel Prize in Chemistry for her work over the past 20 years in October 2018 while this article was being reviewed. The article describes some unusual chemistry her group made a P450 carry out, and is a good representation of the general type of work that won her a Nobel Prize.a. How does the chemistry described in this paper differ from that of a typical P450 cytochrome?b.They use a P450 with an unusual serine-ligated heme instead of the normal conserved cysteine. How did they arrive at the decision to use this unusual enzyme as a starting point for optimizing the activity (at least as described in the paper itself)?c.In the paper, they refer to ‘total turnover number (TTN)’ as an important measure. What does this term actually mean?d.Surprisingly, removal of the P450BM-3 mutant’s FAD domain resulted in higher, not lower, activity. What are two things this confirms or reveals about the chemistry?
After completing the required readings listed above, read the following case study: Meltdown at Koeberg Meltdown at Koeberg – Alternative FormatsOnce you have read the case study, write a 3-4 page paper (although feel free to write more if you want) that addresses each of the following topics. Be sure your paper fully explains your ideas, using points from the case study, as well as the required readings (and/or other appropriate sources). Your paper should be double-spaced, with 12-point font, and 1” margins and needs to be written as an APA-formatted essay [see the mail message sent out the first week of class for full details]. In terms of human resources management, explain what you see as the most significant problem(s) in this case study. Identify and explain what elements of job design (or job re-design) might be most helpful to Dr. Behr as he seeks to improve operations at Koeberg District Hospital. Describe the “climate for motivation” at the hospital and then, using specific and practical ‘tools of engagement’ (Berman, Bowman, West, & Van Wart, 2016, pp. 228-235) explain what can be done to improve the level of motivation.As noted above, your Case Study Analysis paper needs to be in the form of an essay.
Write an expository essay in which you assess the news media coverage of the coronavirus pandemic globally.
Class#5 HW: Compare and Contrast and Read Practical Art CriticismPart 1: Compare and Contrast with Pollockhttps://www.moma.org/calendar/exhibitions/1085?Visit MoMA’s 2011 Exhibition. Use the link to interactive exhibition tour to locate one other Ab Ex painting. 1.Analyze the Work and write at least 20 statements comparing and contrasting this work to Pollock’s2.What emotion, energy, phychology,etc. Does this painting communicate in contrast to the Pollock?
Imagine you are talking to a friend or loved one and that person asks you: What is the Republic about? Provide a response to that person, but the response must satisfy the following requirements:Your main idea must focus on one of the following themes: conflict, culture/society, education, happiness, justice, philosophy, or politics. The explanation of your main idea must provide paraphrased, accurate textual analysis and evidence. Your response must address the follow-up question that your friend or loved-one has: How does what you say about the Republic relate to our world, the real world?
