Hypothesis: Stapled Peptides are Novel Cell Penetrating Peptide that Enhance Cellular Uptake of Conjugated Antisense Oligonucleotides. Also, answer these Research Questions in my project: 1. How do PMO enter cells? 2. Do peptide conjugates facilitate cell entry of PMOs? a. If so How? 3. How do Stapled peptides enter cells a. Are they attractive alternatives to other peptide conjugates for PMO delivery.