Hypothesis: Stapled Peptides are Novel Cell Penetrating Peptide that Enhance Cellular Uptake of Conjugated Antisense Oligonucleotides. Also, answer these Research Questions in my project: 1. How do PMO enter cells? 2. Do peptide conjugates facilitate cell entry of PMOs? a. If so How? 3. How do Stapled peptides enter cells a. Are they attractive alternatives to other peptide conjugates for PMO delivery.
In a formal paper of 1,000-1,250 words you will discuss the work of the Robert Wood Johnson Foundation Committee Initiative on the Future of Nursing and the Institute of Medicine research that led to the IOM report, “Future of Nursing: Leading Change, Advancing Health.” Identify the importance of the IOM “Future of Nursing” report related to nursing practice, nursing education and nursing workforce development. What is the role of state-based action coalitions and how do they advance goals of the Future of Nursing: Campaign for Action? Explore the Campaign for Action webpage (you may need to research your state’s website independently if it is not active on this site): http://campaignforaction.org/states Review your states progress report by locating your state and clicking on one of the six progress icons for: education, leadership, practice, interpersonal collaboration, diversity, and data. You can also download a full progress report for your state by clicking on the box located at the bottom of the webpage. In a paper of 1,000-1,250 words: Discuss the work of the Robert Wood Johnson Foundation Committee Initiative on the Future of Nursing and the Institute of Medicine research that led to the IOM report, “Future of Nursing: Leading Change, Advancing Health.” Identify the importance of the IOM Future of Nursing report related to nursing practice, nursing education and nursing workforce development. What is the role of state-based action coalitions and how do they advance goals of the Future of Nursing: Campaign for Action? Summarize two initiatives spearheaded by your states action coalition. In what ways do these initiatives advance the nursing profession? What barriers to advancement currently exist in your state? How can nursing advocates in your state overcome these barriers? A minimum of three scholarly references are required for this assignment.
For this assignment, compare and contrast two communication techniques that can be used to improve employee trust and engagement. Feel free to use the channels or techniques discussed in Communication Provides Foundation for Being a Best Place to Work by Kathleen Skidmore-Williamsan article that is located in the Unit IV Required Reading sectionor feel free to research your own. Your assignment should include the components below: Explain why communication is essential in an organization. Explain the ways that effective communication improves employee trust and engagement. Focus on comparing/contrasting two types of channels or techniques (e.g., on-site meetings, employee surveys, workshops). Explain the types of situations where each channel or technique would be most effective.
1. Description of the Microorganism: a. Write a paragraph describing your organism. Please be sure to include the type of organism (bacterial, viral, fungal, protozoa, helminth, etc), morphology (shape, arrangement, colony morphology if applicable), description of structure (gram result, type of nucleic acid or virion structure, spore type, etc if applicable) and also the type of microscope and/or stain you would use to view the organism. Please use proper scientific terminology and good grammar and sentence structure throughout this project. 2. Virulence Factors: a. Include a paragraph on the virulence factors the pathogen has and how they affect the host. Please enhance this with detailed explanations of the virulence factors and how they affect the host as you gain a better understanding of them throughout the semester. 3. Immunity: a. Which defenses protect us from infection by this bacterium? b. Does this pathogen induce a specific type of immune response (example: delayed-type hypersensitivity)? If so, which one(s)? 4. Infectious Disease Information: a. What condition(s) or infectious diseases does it cause? b. Which tissues or organs are affected, and how are they affected (for example, chronic TB is characterized by lung tubercles)? c. Describe the complications that can result if the infection is left untreated. d. Are these acute, chronic, or latent infections? e. What organ system(s) does it infect? f. Is it an opportunistic pathogen? If so, where is it normally found in the body? 5. Epidemiology: a. Draw and label diagram on how this organism is transmitted. Make sure you include the reservoirs of infection, and vectors in involved in transmission, the type of transmission and the portals of entry and exit. 6. Presentations: a. Provide a written, detailed description of a hypothetical patient. Be imaginative and create a hypothetical situation that would correspond with your microorganism. This is expected to be at least 8-10 sentences in length and is expected to be comprehensive and detailed. You are expected to include descriptions of: i. Signs and symptoms, using correct terminology ii. Patient history, including any situation that could expect how the infection was acquired (for example, if a food-borne intoxication is involved, when and how it could have been ingested?). iii. Any data-specific indicators that would be important in a clinical setting, for example, urea or sugar levels in the blood or urine, elevated WBC, elevated CO2 levels, etc. 7. Prevention: a. Is there a childhood vaccine against this microbe? Name the vaccine b. If so, when is it administered (the recommended schedule, including boosters)? c. If the vaccine is not recommended during childhood, which at-risk group should get the vaccine, and when? d. Describe the type of vaccine and how it works e. If there is no vaccine available, list at least three measures that can be implemented to prevent transmission of this infection. 8. Treatment: a. Chemotherapeutic agents: b. Mechanism of action for these chemotherapeutic agents: c. Why this agent is efficacious against this particular organism? d. Additional therapeutic agents or practices: 9. Clinical Relevance: a. Are there any Multi-Drug Resistant strains of this microorganism? If so, name the strain(s). b. Is this strain a known healthcare-associated pathogen? c. Which persons/procedures within a clinical or healthcare-assisted settings are particularly at risk? d. Which antibiotics are used against the MDR strains?
Is all data presented relevant to aims and objectives? Is the analysis thorough and appropriate to the data collected, depending on the research methods used? For example: – Do the appendices contain a data matrix, and details of statistical analysis undertaken? Is statistical analysis correctly performed and interpreted? – Do the appendices contain data collected and analysed such as interview transcripts? Has qualitative data been systematically analysed? – Has the validity and reliability of the sources been addressed? Has quantitative or qualitative data been systematically analysed? Are the findings presented clearly and interestingly for the reader, with useful tables and charts embedded in the text and with the appendices being used appropriately for bulky and/or less interesting/essential data? Have the findings been discussed and evaluated? Have the finding of the primary research been compared and contrasted with findings, theories, models and concepts derived from the literature review?
What tactics and methods do they use to influence the Congress and the president?
Discuss Relationship between stress and health and the importance of learning positive measures to ensure our physical and mental well-being.
Discuss what theory of punishment you believe our current judicial system most predominately follows.
What direct involvement by the Federal Government should be initiated and supported concerning the physical security and cybersecurity of the U.S. Power Grid excluding nuclear power facilities?
its a thesis proposal on computer science will submit to ( computer and information school ) The research proposal should be around 2,000 words in length and should contain the following elements: (1)Title of proposed thesis (2)Background to the research topic – it must show why the topic area is interesting and how it is of theoretical and practical significance. It also need to demonstrate what has already been published in this field. (3)Specific aims and (4) objectives – set out what contribution to knowledge this study will make: this could be based on identifying current gaps, areas of contention in the field or new empirical findings. The aim of the project should be clearly stated and should include focused and specific steps (objectives) required to address the aim. (5)Methods of research proposed, and (6) a plan and timetable. The proposal should show an understanding of why and how the chosen methodology will be used. If the proposed plan includes collecting of empirical data, a detailed justification of proposed data collection methods, sampling strategy and methods of analysis should be provided. The proposed plan should be ambitious but feasible to be completed within three years. The proposal should show some awareness of the ethical issues surrounding the proposed research. The suggested research topic is: Investigating computer science students attitude and awareness towards the use of web technologies to enhance their learning outcomes (Case study from a Saudi university) Suggested Methods: Questionnaires and interviews Suggested References: 1- Debates in Computing and ICT Education/ Chapter 8: Using Web technologies to enhance learning and teaching By Leon Cych, Lawrence Williams, Sarah Younie (2018) { web++technologies+to+enhance+higher+education+learning+outcomes&ots=xQ3h6T78Ll&sig=18 ONlbvTaNF_VEWGqq5xCWJVqOs#v=onepage&q=WEB%&f=false } 2- Social Space or Pedagogic Powerhouse: Do Digital Natives Appreciate the Potential of Web Technologies for Learning? ( %20Powerhouse:%20Do%20Digital%20Natives%20Appreciate%20the%20Potential%20of%20Web% %20Technologies%20for%20Learning?) 3-Systematic literature review: Self-Regulated Learning strategies using e-learning tools for Computer Science { 4- E-Learning in the 21st Century By D. Randy Garrison (2011) { } 5- Chen, P. D., Lambert, A. D., & Guidry, K. R. (2010). Engaging online learners: The impact of webbased technology on college student engagement. The research proposal should be around 2,000 words in length and should contain the following elements: (1)Title of proposed thesis (2)Background to the research topic – it must show why the topic area is interesting and how it is of theoretical and practical significance. It also need to demonstrate what has already been published in this field. (3)Specific aims and (4) objectives – set out what contribution to knowledge this study will make: this could be based on identifying current gaps, areas of contention in the field or new empirical findings. The aim of the project should be clearly stated and should include focused and specific steps (objectives) required to address the aim. (5)Methods of research proposed, and (6) a plan and timetable. The proposal should show an understanding of why and how the chosen methodology will be used. If the proposed plan includes collecting of empirical data, a detailed justification of proposed data collection methods, sampling strategy and methods of analysis should be provided. The proposed plan should be ambitious but feasible to be completed within three years. The proposal should show some awareness of the ethical issues surrounding the proposed research. 6-Chugh, R., & Ruhi, U. (2017). Social media in higher education: A literature review of Facebook. 7- Faizi, R., Chiheb, R., & El Afia, A. (2015). Students’ perceptions towards using Web technologies in education. 8- Faizi R., El Fkihi S. (2016b). Incorporating Web technologies in education: Opportunities and challenges. 9- Harris, A. L., & Rea, A. (2009). Web and virtual world technologies: A growing impact on is education. 10- Hrastinski, S., & Aghaee, N. M. (2012). How are campus students using social media to support their studies? An explorative interview study. 11- Knight-McCord, J., Cleary, D., Grant, N., Herron, A., Lacey, T., Livingston, T., & Emanuel, R. (2016). What social media sites do college students use most. 12- Manca, S., & Ranieri, M. (2016). Facebook and the others. Potentials and obstacles of Social Media for teaching in higher education 13- Sobaih, A. E. E., Moustafa, M. A., Ghandforoush, P., & Khan, M. (2016). To use or not to use? Social media in higher education in developing countries. 14- Hartshorne, R. & Ajjan, H. (2009) Examining student decisions to adopt Web technologies: theory and empirical tests
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